Saba T M, Blumenstock F A, Scovill W A, Bernard H
Science. 1978 Aug 18;201(4356):622-4. doi: 10.1126/science.675246.
Human opsonic alpha2-surface binding glyoprotein (alphs2SB-glycoprotein), a molecule having immunologic identity with an amino acid composition similar to cold-insoluble globulin, is concentrated in a cryoprecipitate of plasma. Septic surgical and trauma patients manifesting opsonic alpha2SB-glycoprotein deficiency and associated reticuloendothelial system dysfunction were treated by intravenous infusion of cryoprecipitate. This therapy restored circulating bioreactive and immunoreactive opsonin and improved their septicemia, pulmonary insufficiency, and duration of recovery. Cryoprecipitate infusion may offer a new approach to the treatment of septic injured patients in preventing multiple organ failure; measurement of immuno-reactive serum opsonic alpha2SB-glycoprotein may provide a noninvasive index of reticuloendothelial system function and patient status during servere sepsis that follows trauma.
人调理素α2表面结合糖蛋白（α2SB-糖蛋白）是一种与冷不溶性球蛋白氨基酸组成具有免疫同一性的分子，它集中在血浆冷沉淀物中。表现出调理素α2SB-糖蛋白缺乏及相关网状内皮系统功能障碍的脓毒症外科手术和创伤患者，通过静脉输注冷沉淀物进行治疗。这种疗法恢复了循环中的生物活性和免疫反应性调理素，并改善了他们的败血症、肺功能不全及恢复时间。输注冷沉淀物可能为治疗脓毒症受伤患者以预防多器官功能衰竭提供一种新方法；测量免疫反应性血清调理素α2SB-糖蛋白可能为创伤后严重脓毒症期间网状内皮系统功能和患者状态提供一种非侵入性指标。
