Santucci A, Aguglia F, De Mattia G, Ficara C, Balsano F
Br J Clin Pharmacol. 1982;14 Suppl 2(Suppl 2):77S-79S. doi: 10.1111/j.1365-2125.1982.tb02061.x.
1 The long-term effects of the oral angiotensin-converting enzyme inhibitor captopril with the addition of a diuretic (chlorthalidone) were examined in 16 patients with moderate or grave hypertension. Of these, 14 had essential hypertension and two renovascular hypertension. 2 Blood pressure fell sharply in all patients and this antihypertensive effect was maintained during 2, 4, 6, 12, and 24-month follow-up periods. The efficacy of treatment was not predicted by basal values of plasma renin activity. 3 Urinary excretion of sodium and potassium increased, but the increases were never such as to modify significantly sodium and potassium serum concentration. 4 The long-term treatment was generally well tolerated.
对16例中度或重度高血压患者，研究了口服血管紧张素转换酶抑制剂卡托普利加用利尿剂（氯噻酮）的长期效果。其中14例为原发性高血压，2例为肾血管性高血压。
所有患者血压均急剧下降，且在2个月、4个月、6个月、12个月和24个月的随访期内，这种降压效果得以维持。治疗效果并非由血浆肾素活性的基础值所预测。
钠和钾的尿排泄量增加，但增加幅度从未大到足以显著改变血清钠和钾的浓度。
长期治疗总体耐受性良好。
