Laher M S, O'Regan P, O'Donohoe J F, Counihan T B
J R Soc Med. 1985 May;78(5):367-72. doi: 10.1177/014107688507800504.
The use of captopril in 19 patients with renal parenchymal disease and refractory hypertension was studied for a mean period of 12 months. There was a significant reduction in the systolic and diastolic blood pressures, with a reduction in the mean arterial pressure of 29 mmHg. The mean maintenance dose of captopril was 142 mg daily in three divided doses. All but one of the patients required a diuretic for satisfactory blood pressure control and 3 patients were also given a beta-blocker. In all patients a simplification of the previous therapeutic regimen was achieved. A significant rise in serum creatinine was noted in 2 patients, one of whom had to be withdrawn from the study. Despite the presence of renal functional impairment, proteinuria did not occur de novo nor did established proteinuria increase. Leukopenia was noted in any of the patients in this group.
对19例肾实质疾病合并顽固性高血压患者使用卡托普利进行了研究,平均为期12个月。收缩压和舒张压显著降低,平均动脉压降低29mmHg。卡托普利的平均维持剂量为每日142mg,分三次服用。除1例患者外,所有患者均需要使用利尿剂以满意控制血压,3例患者还给予了β受体阻滞剂。所有患者均实现了既往治疗方案的简化。2例患者血清肌酐显著升高,其中1例不得不退出研究。尽管存在肾功能损害,但未出现新发蛋白尿,已有的蛋白尿也未增加。该组患者均未出现白细胞减少。