Morgan D J, Phillips M J, Moodley I, Elliott E V, Davies R J
Clin Allergy. 1982 Oct;12 Suppl:29-37. doi: 10.1111/j.1365-2222.1982.tb03296.x.
Significant increase in the maximum post-exercise values of plasma histamine (PH), whole blood histamine (WBH) and neutrophil chemotactic factor (NCF) occurred in arterial blood within the first hour after exercise in asthmatic patients. However, similar changes in PH and WBH also occurred in the control group. Significant increases in circulating basophil counts following exercise were found in both groups, which closely mirrored the changes in PH and NCF, and there was a highly significant correlation between rises in WBH and basophil counts (P less than 0.001). When plasma histamine as assayed in venous blood using a more sensitive and specific double isotope radio enzymatic assay no significant alteration in plasma histamine levels was detected in either the asthmatic or the control group. We conclude that there is no evidence from these studies to support the suggestion that mast cell mediator release is involved in the pathogenesis of exercise-induced asthma, and that any observed changes in levels of PH and NCF after exercise may be related to changes in levels of circulating basophils.
哮喘患者运动后1小时内，动脉血中血浆组胺（PH）、全血组胺（WBH）和中性粒细胞趋化因子（NCF）的运动后最高值显著增加。然而，对照组的PH和WBH也出现了类似变化。两组运动后循环嗜碱性粒细胞计数均显著增加，这与PH和NCF的变化密切相关，WBH升高与嗜碱性粒细胞计数之间存在高度显著相关性（P小于0.001）。当使用更灵敏和特异的双同位素放射酶法检测静脉血中的血浆组胺时，哮喘组和对照组的血浆组胺水平均未检测到显著变化。我们得出结论，这些研究没有证据支持肥大细胞介质释放参与运动诱发性哮喘发病机制的观点，运动后观察到的PH和NCF水平变化可能与循环嗜碱性粒细胞水平的变化有关。
