运动诱发哮喘期间的血小板活化：色甘酸和沙丁胺醇预防的效果

Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol.

作者信息

Johnson C E, Belfield P W, Davis S, Cooke N J, Spencer A, Davies J A

出版信息

Thorax. 1986 Apr;41(4):290-4. doi: 10.1136/thx.41.4.290.

DOI:10.1136/thx.41.4.290

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC460312/

Abstract

Peak expiratory flow (PEF) and plasma concentrations of platelet factor 4 and beta thromboglobulin were measured before and after exercise in nine asthmatic patients and 12 non-asthmatic volunteers. Exercise was preceded by administration in random order of either placebo, salbutamol 200 micrograms, or sodium cromoglycate 2 mg from a pressurised inhaler. In control subjects there were minimal changes in PEF and plasma concentrations of platelet factor 4 and beta thromboglobulin. In the asthmatic patients the typical changes in PEF were seen on exercise; plasma concentrations of platelet factor 4 and beta thromboglobulin rose significantly in parallel, the rise preceding the fall in PEF. The changes in peak flow and platelet activation induced by exercise were attenuated by prior administration of salbutamol or cromoglycate. These results indicate that exercise induced asthma is associated with a rise in platelet release products similar to that observed in antigen induced asthma.

摘要

在9名哮喘患者和12名非哮喘志愿者运动前后，分别测量了其呼气峰值流速（PEF）以及血浆中血小板因子4和β-血小板球蛋白的浓度。运动前，随机顺序给予安慰剂、200微克沙丁胺醇或2毫克色甘酸钠气雾剂。在对照组中，PEF以及血浆中血小板因子4和β-血小板球蛋白的浓度变化极小。哮喘患者在运动时出现了典型的PEF变化；血浆中血小板因子4和β-血小板球蛋白的浓度显著平行升高，且升高先于PEF下降。预先给予沙丁胺醇或色甘酸钠可减轻运动引起的峰值流速变化和血小板活化。这些结果表明，运动诱发的哮喘与血小板释放产物增加有关，这与抗原诱发的哮喘中观察到的情况相似。

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