Weiss R C, Scott F W
Comp Immunol Microbiol Infect Dis. 1981;4(2):175-89. doi: 10.1016/0147-9571(81)90003-5.
Non-immune kittens passively immunized with feline serum containing high-titered antibodies reactive with feline infectious peritonitis virus (FIPV) developed a more rapid disease after FIPV challenge than did kittens pretreated with FIPV antibody-negative serum. Antibody-sensitized, FIPV challenged--kittens developed earlier clinical signs (including pyrexia, icterus, and thrombocytopenia) and died more rapidly than did non-sensitized, FIPV-challenged kittens. Mean survival time in sensitized kittens was significantly (P less than 0.05) reduced compared to non-sensitized kittens (mean +/- SEM, 10.0 +/- 0.6 days vs. 28.8 +/- 8.3 days, respectively). Lesions induced included fibrinous peritonitis, disseminated pyogranulomatous inflammation and necrotizing phlebitis and periphlebitis. FIPV antigen, immunoglobulin G, complement (C3) and fibrinogen were demonstrated in lesions by immunofluorescence microscopy. The pathogenesis of dengue hemorrhagic fever (DHF) in persons bears striking resemblance to that of FIP in experimental kittens. In both FIP and DHF, non-neutralizing antibody may promote acute disease by enhancement of virus infection in mononuclear phagocytes or by formation of immune complexes, activation of complement and secondary vascular disturbances.
用含有与猫传染性腹膜炎病毒（FIPV）反应的高滴度抗体的猫血清进行被动免疫的非免疫小猫，在受到FIPV攻击后比用FIPV抗体阴性血清预处理的小猫发病更快。抗体致敏、FIPV攻击的小猫出现临床症状（包括发热、黄疸和血小板减少）的时间更早，且比未致敏、FIPV攻击的小猫死亡更快。与未致敏小猫相比，致敏小猫的平均存活时间显著缩短（P小于0.05）（平均±标准误，分别为10.0±0.6天和28.8±8.3天）。诱导的病变包括纤维素性腹膜炎、播散性脓性肉芽肿性炎症、坏死性静脉炎和静脉周炎。通过免疫荧光显微镜在病变中检测到FIPV抗原、免疫球蛋白G、补体（C3）和纤维蛋白原。登革出血热（DHF）在人类中的发病机制与实验小猫中的FIP惊人地相似。在FIP和DHF中，非中和抗体可能通过增强单核吞噬细胞中的病毒感染或通过形成免疫复合物、激活补体和继发性血管紊乱来促进急性疾病。
