甲基泼尼松龙抑制补体的替代途径和扩增途径。
Methylprednisolone inhibits the alternative and amplification pathways of complement.
作者信息
Weiler J M, Packard B D
出版信息
Infect Immun. 1982 Oct;38(1):122-6. doi: 10.1128/iai.38.1.122-126.1982.
Abstract
Methylprednisolone sodium succinate limited the ability of zymosan or lipopolysaccharide to activate complement in normal serum by the alternative amplification pathways. Methylprednisolone limited B consumption in a reaction mixture which contained purified C3b, D, and B, indicating that soluble steroid directly inhibited the amplification pathway. The ability of soluble steroid to inhibit events in the alternative and amplification pathways of complement may provide a partial explanation for the effectiveness of steroids in treating gram negative septic shock.
摘要
琥珀酸甲泼尼龙可限制酵母聚糖或脂多糖通过替代途径激活正常血清中的补体。甲泼尼龙可减少反应混合物中B因子的消耗，该混合物含有纯化的C3b、D因子和B因子，这表明可溶性类固醇直接抑制替代途径。可溶性类固醇抑制补体替代途径和放大途径中相关事件的能力，可能为类固醇治疗革兰氏阴性败血症休克的有效性提供部分解释。
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