Grunfeld B, Gimenez M, Liapchuc S, Mendilaharzu J, Gianantonio C
Int J Pediatr Nephrol. 1982 Sep;3(3):211-4.
A group of 21 children with HUS underwent serial estimations of PRA and blood pressure. At time of administration PRA was 13.2 divided by 1.59 ng/ml/hr (mean + SE), in seven who were hypertensive the mean was 14.1 +/- 3.2 ng/ml/hr and despite the wide range PRA was considered to be elevated in 6 of this group. The 14 normotensive children had a mean PRA of 12.8 +/- 1.8 ng/ml/hr, only 1 patient having a value within the normal range. In 9 children PRA was normal once diuresis had been established (9 +/- 1.4 ng/ml/hr) and only two patients of this group were hypertensive at time of the study. PRA measured in 8 children 4 weeks after presentation was 7 +/- 1.6 ng/ml/hr, and 3 hypertensive children having a mean value of 7.5 ng/ml/hr and the 5 normotensive children a mean of 2.5 ng/ml/hr. The data indicate that activation of the renin-angiotensin system in HUS occurs irrespective of hypertension. Furthermore blood pressure levels were not correlated to the degree of hydration.
一组21名溶血尿毒综合征患儿接受了肾素活性（PRA）和血压的系列评估。给药时PRA为13.2除以1.59 ng/ml/小时（均值±标准误），7名高血压患儿的均值为14.1±3.2 ng/ml/小时，尽管范围较宽，但该组中有6名患儿的PRA被认为升高。14名血压正常的患儿PRA均值为12.8±1.8 ng/ml/小时，只有1名患者的值在正常范围内。9名患儿在利尿确立后PRA正常（9±1.4 ng/ml/小时），该组中只有2名患者在研究时患有高血压。8名患儿在就诊4周后测得的PRA为7±1.6 ng/ml/小时，3名高血压患儿的均值为7.5 ng/ml/小时，5名血压正常的患儿均值为2.5 ng/ml/小时。数据表明，溶血尿毒综合征中肾素-血管紧张素系统的激活与高血压无关。此外，血压水平与水合程度无关。
