Greenberg J, McKeever P E, Balentine J D
Surg Neurol. 1978 Jun;9(6):361-4.
The possible role of lysosomal activity in the early post-trauma phase of severe experimental spinal cord trauma was assessed utilizing an acid phosphatase cytochemical ultrastructural study. The results indicate that there is no evidence for lysosomal alteration prior to the development of cellular degeneration or necrosis. No diffuse cytoplasmic staining was observed. This study indicates that physical lysosomal injury resulting in release of hydrolases into spinal cord cells is not a tenable hypothesis as a primary initiating event in the development of spinal cord necrosis following trauma. However, the data are consistent with the general theory that lysosomal activity is important in the secondary degradation of cells following their being altered beyond recovery.
利用酸性磷酸酶细胞化学超微结构研究评估了溶酶体活性在严重实验性脊髓损伤创伤后早期阶段可能发挥的作用。结果表明，在细胞变性或坏死发生之前，没有证据表明溶酶体发生改变。未观察到弥漫性细胞质染色。本研究表明，导致水解酶释放到脊髓细胞中的物理性溶酶体损伤，作为创伤后脊髓坏死发展过程中的主要起始事件，并不是一个合理的假设。然而，这些数据与一般理论一致，即溶酶体活性在细胞发生无法恢复的改变后的继发性降解过程中很重要。
