Fornaro M, Hess O, Benoist F, Turina M
Thoraxchir Vask Chir. 1978 Jun;26(3):190-3. doi: 10.1055/s-0028-1096621.
Haemodynamic changes after intracoronary air embolism (0,02 ml/kg air in the left coronary artery) were studied in 16 dogs. The air was introduced in 8 animals during cardiopulmonary bypass and in 8 animals without bypass. In both groups the air embolization caused acute ischemia with myocardial necrosis. Immediately after the injection the anterior wall became akinetic; 24 hours after injection CPK increased to more than 800 U. One half of the animals without cardiopulmonary bypass died during acute ischemia due to refractory arrhythmias; there was no mortality in the group with cardiopulmonary bypass. The left ventricular damage due to air embolization cannot be significantly reduced with cardiopulmonary bypass; the bypass only helps to "tide over" the animal during the period of acute ischemia.
对16只犬进行了冠状动脉内空气栓塞（左冠状动脉内注入0.02 ml/kg空气）后的血流动力学变化研究。8只动物在体外循环期间注入空气，8只动物未进行体外循环时注入空气。两组中空气栓塞均导致急性缺血并伴有心肌坏死。注射后立即出现前壁运动不能；注射后24小时肌酸磷酸激酶（CPK）升高至800 U以上。未进行体外循环的动物中有一半在急性缺血期间因顽固性心律失常死亡；体外循环组无死亡病例。体外循环并不能显著减轻空气栓塞所致的左心室损伤；体外循环仅有助于动物在急性缺血期“度过难关”。
