Cohen A I, Devlin R G, Ivashkiv E, Funke P T, McCormick T
J Pharm Sci. 1982 Nov;71(11):1251-6. doi: 10.1002/jps.2600711117.
A modified electron-impact GLC-selected ion monitoring mass spectrometric method for captopril is described. Positive chemical ionization GLC-selected ion monitoring and direct chemical ionization confirms the specificity of this procedure for captopril and establishes the chemical ionization techniques as potential analytical methods. This procedure has been adapted to the simultaneous measurement of captopril and its isotopomer. The results of a pilot oral bioavailability study of four subjects receiving either 100 mg of captopril as a direct compression tablet or a solution concomitantly with a 100-mg solution of isotopomer is discussed.
描述了一种用于卡托普利的改进型电子轰击气相色谱-选择离子监测质谱法。正化学电离气相色谱-选择离子监测和直接化学电离证实了该方法对卡托普利的特异性，并将化学电离技术确立为潜在的分析方法。该方法已适用于同时测定卡托普利及其同位素异构体。讨论了对四名受试者进行的初步口服生物利用度研究的结果，这些受试者分别接受100 mg直接压片的卡托普利或溶液，同时服用100 mg同位素异构体溶液。
