Araki G, Mihara H, Mizukami M, Kin H, Nishijima M, Yoshida Y
Stroke. 1978 Jul-Aug;9(4):364-8. doi: 10.1161/01.str.9.4.364.
Cerebral atherosclerosis without luminal narrowing has been found macroscopically and by angiographic examinations in some patients with cerebral hemorrhage. In order to clarify the histology of non-stenotic atherosclerosis of the cerebral vessels, we examined cleared specimens and serial sections of the main trunks of the cerebral arteries. The middle cerebral artery was selected in 20 cases of cerebral hemorrhage and 7 cases of cerebral infarction. Non-stenotic atherosclerosis was found frequently in cases of cerebral hemorrhage, while most patients with cerebral infarction showed stenotic cerebral atherosclerosis. We counted the numbers of medial smooth muscle cells in 10 autopsied cases of cerebral hemorrhage and 6 of cerebral infraction. The mean numbers of smooth muscle cells per unit area in the patient with cerebral hemorrhage were less than those in cerebral infraction. In cerebral hemorrhage, the main trunks of the cerebral arteries were dilated, probably as a result of the damage to medial muscle cells and higher blood pressure during the course of intimal thickening. It is considered that arterial hypertension spreads to the peripheral, small arteries through the main trunks without luminal narrowing of the cerebral vessels.
在一些脑出血患者中，通过宏观检查和血管造影检查发现了无管腔狭窄的脑动脉粥样硬化。为了阐明脑血管非狭窄性动脉粥样硬化的组织学特征，我们检查了脑动脉主干的透明标本和连续切片。选取了20例脑出血病例和7例脑梗死病例的大脑中动脉。脑出血病例中经常发现非狭窄性动脉粥样硬化，而大多数脑梗死患者表现为狭窄性脑动脉粥样硬化。我们对10例脑出血尸检病例和6例脑梗死病例的中膜平滑肌细胞数量进行了计数。脑出血患者每单位面积平滑肌细胞的平均数量少于脑梗死患者。在脑出血中，脑动脉主干扩张，这可能是由于在内膜增厚过程中中膜肌细胞受损和血压升高所致。据认为，动脉高血压通过脑主干血管传播到外周小动脉，而脑主干血管无管腔狭窄。
