Kirber M W, Kirber H P, Dubin I N, Carson B A, Savage A M
Ophthalmologica. 1977;174(3):158-66. doi: 10.1159/000308594.
Autoimmune disease has been suspected in some cases of human uveitis. The initiating event has been thought to be injury and/or infection. To investigate the effect of injury on the uvea and on the immune apparatus rabbits and guinea pigs were subjected to various repeated iris insults, including implantation of autologous iris tissue into the anterior chamber of the contralateral eye. Of the procedures employed only iridectomy and insertion of iris produced some anterior chamber clouding, which was only slightly increased on repetition of the procedure; 76% of these animals failed to produce circulating CF antibodies. No local CF antibodies in the anterior chamber fluid nor increases in fluorescent antibodes in sections of the eyes could be detected. None of the animals tested developed skin hypersensitivity to homologous uveal antigen. None of the other traumatic procedures, which included repeated insertions of plastic into the anterior chamber, produced uveitis manifested clinically or by histological examination, circulating or local humoral antibodies, nor increases in fluorescent antibodies in the tissues of the eye. Introduction of antiuveal antibody into the anterior chamber also failed to produce uveitis. It can be concluded from these experiments that simple, repeated injury to the iris is not sufficient to elicit an autoimmune response under the conditions tested.
在某些人类葡萄膜炎病例中，怀疑存在自身免疫性疾病。引发事件被认为是损伤和/或感染。为了研究损伤对葡萄膜和免疫器官的影响，对兔子和豚鼠进行了各种反复的虹膜损伤，包括将自体虹膜组织植入对侧眼的前房。在所采用的操作中，只有虹膜切除术和虹膜植入会导致一些前房混浊，在重复该操作时仅略有增加；这些动物中有76%未能产生循环CF抗体。在前房液中未检测到局部CF抗体，在眼部切片中也未检测到荧光抗体增加。所测试的动物均未对同源葡萄膜抗原产生皮肤超敏反应。其他创伤性操作，包括将塑料反复插入前房，均未产生临床上或组织学检查显示的葡萄膜炎、循环或局部体液抗体，也未使眼部组织中的荧光抗体增加。向前房内注入抗葡萄膜抗体也未能产生葡萄膜炎。从这些实验可以得出结论，在测试条件下，简单、反复的虹膜损伤不足以引发自身免疫反应。
