Audain V P, Vethamany V G, Quigley J, Ghose T
Can J Ophthalmol. 1978 Apr;13(2):96-101.
We developed an experimental model of anterior uveitis by injecting ovalbumin or bovine serum albumin into the anterior chamber of sensitized rabbits. All the eyes showed leakage of serum proteins into the aqueous humor within 30 min. and developed uveitis within 24 hrs. which lasted at least a week. On histological examination, large numbers of polymorphonuclear (PMN) leucocytes and only occasional mononuclear cells were seen in the iris, the ciliary body and the irido-corneal angle. Immunohistological examination revealed 7s gamma globulin in the walls of blood vessels, in the interstitium and inside the PMN leucocytes. Contact radiographs of eyes challenged repeatedly showed extensive neovascularization of the iris and ciliary body.
我们通过将卵清蛋白或牛血清白蛋白注射到致敏兔的前房来建立前葡萄膜炎实验模型。所有眼睛在30分钟内均出现血清蛋白渗漏到房水中，并在24小时内发生葡萄膜炎，且持续至少一周。组织学检查显示，在虹膜、睫状体和虹膜角膜角可见大量多形核（PMN）白细胞，仅偶尔可见单核细胞。免疫组织学检查显示，在血管壁、间质和PMN白细胞内有7sγ球蛋白。反复受挑战的眼睛的接触X线照片显示虹膜和睫状体有广泛的新生血管形成。
