Durrington P N
Crit Rev Clin Lab Sci. 1982;18(1):31-78. doi: 10.3109/10408368209082589.
The known limitations and advantages of methods for determining serum high-density lipoprotein (HDL) cholesterol concentration are reviewed with special emphasis on the applicability of each method to clinical medicine. The evidence for and against the relevance of serum HDL cholesterol to the prediction of the likelihood of an individual man or woman developing clinically evident ischemic heart disease is discussed. The possibility that HDL subfractions may be more relevant to this issue is also discussed. Information about serum HDL cholesterol concentration in diseases other than ischemic heart disease is reviewed. The effect of diet, body-weight, exercise, cigarette-smoking, alcohol intake, and hyperlipoproteinemia and the effect of modification of these factors on serum HDL cholesterol levels is discussed. Finally, a practical approach to the patient with a low concentration of serum HDL cholesterol is suggested.
本文回顾了测定血清高密度脂蛋白（HDL）胆固醇浓度方法的已知局限性和优点，特别强调了每种方法在临床医学中的适用性。讨论了支持和反对血清HDL胆固醇与预测个体男性或女性发生临床明显缺血性心脏病可能性相关的证据。还讨论了HDL亚组分可能与该问题更相关的可能性。综述了缺血性心脏病以外其他疾病中血清HDL胆固醇浓度的信息。讨论了饮食、体重、运动、吸烟、饮酒和高脂蛋白血症的影响以及这些因素的改变对血清HDL胆固醇水平的影响。最后，提出了针对血清HDL胆固醇浓度低的患者的实用方法。
