[麻风病患者多形核中性粒细胞对白色念珠菌和伪热带念珠菌的吞噬作用及溶解作用]
[Phagocytosis and lysis of Candida albicans and Candida pseudotropicalis by polymorphonuclear neutrophils of Hansen's disease patients].
作者信息
Fliess E L, Comesaña G, Carrara R C, España A
出版信息
Hansenol Int. 1981 Dec;6(2):109-13.
The phagocytosis and lysis of Candida albicans and Candida pseudotropicalis by human neutrophils were examined in 43 hanseniasis patients (19 quiescent virchowians, 12 reactional virchowians and 12 tuberculoid patients) and 15 healthy subjects. The purpose of this study was to determine whether neutrophils from hanseniasis patients were altered in their enzyme systems myeloperoxidase-dependent (tested by lysin of Candida albicans) and myeloperoxidase-independent (tested by lysin of Candida pseudotropicalis). The results indicate that polymorphonuclear neutrophils of hanseniasis patients had a similar candidacidal activity that human normal neutrophils (p greater than 0.2) in their myeloperoxidase-dependent and myeloperoxidase-independent systems. The enzymatic system activity is also similar in all clinical forms of hanseniasis (p greater than 0.3).
在43例麻风病患者（19例静止期瘤型麻风患者、12例反应性瘤型麻风患者和12例结核样型患者）和15名健康受试者中，检测了人类中性粒细胞对白色念珠菌和伪热带念珠菌的吞噬作用及溶解作用。本研究的目的是确定麻风病患者的中性粒细胞在其髓过氧化物酶依赖性（通过白色念珠菌溶菌素检测）和髓过氧化物酶非依赖性（通过伪热带念珠菌溶菌素检测）酶系统中是否发生改变。结果表明，麻风病患者的多形核中性粒细胞在其髓过氧化物酶依赖性和髓过氧化物酶非依赖性系统中具有与人类正常中性粒细胞相似的杀念珠菌活性（p大于0.2）。在麻风病的所有临床类型中，酶系统活性也相似（p大于0.3）。
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