Dinsmore C E
J Embryol Exp Morphol. 1982 Oct;71:109-20.
Tail skin cuffs have been grafted to the upper forelimb of red-backed salamanders in either normal or 180 degrees-rotated dorsoventral orientation. Subsequent amputation through the graft region resulted in arrested regeneration, distally deficient or typical four-digit regenerates. Distribution was not substantially influenced by graft orientation nor were there any supernumerary limbs induced by the axially dislocated tail skin on the limb stumps. Furthermore, regenerates bore no indication of tail-like structures other than large granular skin glands proximally. These data indicate that, unlike limb skin, tail skin is not morphogenetically active in the epimorphic process of limb regeneration. In addition, the species used in this study is a fin-less, round-tailed salamander. It is therefore suggested that the previously reported morphogenetic effects of tail skin on limb regeneration may be related to the presence of tail fins on the species studied.
已将尾皮袖口移植到红背蝾螈的前肢上部，移植方向为正常背腹方向或旋转180度的背腹方向。随后在移植区域进行截肢，导致再生停滞、远端缺陷或典型的四指再生。分布情况基本不受移植方向的影响，肢体残端上轴向错位的尾皮也未诱导出多余肢体。此外，再生肢体除了近端有大颗粒状皮肤腺外，没有任何尾状结构的迹象。这些数据表明，与肢体皮肤不同，尾皮在肢体再生的形态发生过程中没有形态发生活性。此外，本研究中使用的物种是一种无鳍、圆尾蝾螈。因此，有人提出，先前报道的尾皮对肢体再生的形态发生作用可能与所研究物种的尾鳍有关。
