Dinsmore C E
J Exp Zool. 1981 Feb;215(2):151-64. doi: 10.1002/jez.1402150204.
As an epimorphic system, the urodele tail has much in common with the urodele limb, relative to tissue components. In an effort to elucidate potentially similar functions of the skin during regeneration, two procedures which have been shown to be highly disruptive of limb morphogenesis were performed on the tail. In the first, cuffs of tail skin were rotated 180 degrees about the long axis of tails in Plethodon cinereus. Subsequent amputation through the rotated cuffs produced regenerates at a normal rate which were also normal in both internal architecture and skin gland distribution. In a second series, cuffs of tail skin were rotated 90 degrees about the dorso-ventral axis of the tail, such that the dorsal red stripe encircled the tail. Upon amputation through the middle of the cuff, the stump skin presented an exclusively dorsal surface which, nevertheless, had no effect upon the morphogenetic success of the regenerate. These data therefore indicate that a tissue, such as skin, may be inconsistent in its morphogenetic influence among epimorphic fields within the same organism. It is not clear whether these results reflect differences in field behavior or in absolute tissue potential determined by the field of origin. A tissue hierarchy of morphogenetic influence within and among epimorphic fields is suggested as a preliminary framework within which to coordinate such information.
作为一种再生系统，蝾螈的尾巴与蝾螈的肢体在组织成分方面有许多共同之处。为了阐明再生过程中皮肤可能具有的相似功能，对尾巴进行了两种已被证明对肢体形态发生有高度干扰作用的操作。第一种方法是，在灰口螈中，将尾巴皮肤的皮圈绕尾巴的长轴旋转180度。随后通过旋转的皮圈进行截肢，再生以正常速度进行，再生肢体的内部结构和皮肤腺体分布也都正常。在第二个系列实验中，将尾巴皮肤的皮圈绕尾巴的背腹轴旋转90度，使背部的红色条纹环绕尾巴。在通过皮圈中部进行截肢后，残端皮肤呈现出完全的背侧表面，然而，这对再生肢体的形态发生成功没有影响。因此，这些数据表明，像皮肤这样的组织，在同一生物体的再生系统中，其形态发生影响可能是不一致的。目前尚不清楚这些结果是反映了再生系统行为的差异，还是反映了由起源部位决定的绝对组织潜能的差异。在再生系统内部和之间，形态发生影响的组织层次结构被认为是一个初步框架，用于协调此类信息。
