Cosgrove R F, Forster T C, Jones G T, Pickles R W
J Vet Pharmacol Ther. 1981 Mar;4(1):39-42. doi: 10.1111/j.1365-2885.1981.tb00708.x.
Escherichia coli isolated from pigs fed on a medicated diet containing 120 p.p.m. halquinol did not develop any resistance to this addition over a 6-week period. Sensitivity patterns of the E. coli isolates to eight antimicrobial substances, although fluctuating slightly during the test period (but no more than a control group), did not significantly alter. However, the patterns did change significantly when for 17 days after the completion of the halquinol trial the pigs were fed a normal commercial ration medicated with a commonly used feed additive containing chlortetracycline hydrochloride, procaine penicillin and sulphadimidine.
从食用含120 ppm卤喹醇药物饲料的猪中分离出的大肠杆菌，在6周时间内对这种添加物未产生任何耐药性。大肠杆菌分离株对八种抗菌物质的敏感性模式，尽管在试验期间略有波动（但不超过对照组），但并未显著改变。然而，在卤喹醇试验结束后的17天里，当给猪喂食添加了常用饲料添加剂（含盐酸金霉素、普鲁卡因青霉素和磺胺二甲嘧啶）的正常商业日粮时，这种模式发生了显著变化。
