Wenk P, Wegerhof P H
Z Parasitenkd. 1982;68(3):321-9. doi: 10.1007/BF00927410.
Cotton rats infected by infective third-stage larvae of Litomosoides carinii were treated at increasing time intervals by a threefold injection of living homologous microfilariae (mf) during the prepatent period. Starting with the first treatment 3, 4 or 5 weeks p.i. seven animals remained completely and two almost mf-negative (1 or 2 mf/mm3 each only once) until 16 weeks p.i. Starting 6, 7 or 8 weeks p.i. six animals developed a normal level of parasitaemia between 42 and 436 mf/mm3, two animals developed a continuous level of 1-2 mf/mm3. The number of fertile adult worms shedding great numbers of microfilariae in the pleural cavity was equal in all animals. However, in mf-negative animals the lung capillary blood showed, in the geometric mean, only 0.6% of the mf-concentration seen in mf-positive animals. The hypothesis is proposed that microfilariae accumulating primarily in the lung capillaries absorb all aggressive components specifically reacting with microfilarial antigens, i.e. neutralize the immune response against them to enable the development of the parasitaemia in the peripheral blood.
感染卡氏丝虫感染性三期幼虫的棉鼠，在潜伏期以递增的时间间隔，通过三倍剂量注射活的同源微丝蚴（mf）进行治疗。从感染后3、4或5周开始首次治疗，7只动物直至感染后16周一直完全无mf，2只动物几乎无mf（每只仅一次为1或2 mf/mm³）。从感染后6、7或8周开始，6只动物的寄生虫血症水平正常，在42至436 mf/mm³之间，2只动物的寄生虫血症水平持续为1 - 2 mf/mm³。所有动物胸腔内排出大量微丝蚴的可育成虫数量相同。然而，在无mf的动物中，肺毛细血管血中mf浓度的几何平均值仅为有mf动物的0.6%。提出的假说是，主要积聚在肺毛细血管中的微丝蚴吸收了所有与微丝蚴抗原特异性反应的攻击性成分，即中和了针对它们的免疫反应，从而使外周血中出现寄生虫血症。
