Dzhaparidze M N, Nikitina G P, Ivanov N R, Rystsova E A, Udalova I B
Zh Mikrobiol Epidemiol Immunobiol. 1982(11):29-33.
Oral cholera vaccine contains 45% of O-antigen (serovars Ogawa and Inaba in equal parts) and at least 9 serologically active proteins; of these, toxoid (about 60% of the total amount of protein) and 5 enzymes have been identified: neuraminidase, proteinase, ribonuclease, phospholipase and ATPase. The safety, absence of reactogenicity and definite immunological effectiveness of the preparation in the primary immunization of volunteers have been shown.
口服霍乱疫苗含有45%的O抗原（小川型和稻叶型血清型各占一半）以及至少9种具有血清学活性的蛋白质；其中，已鉴定出类毒素（约占蛋白质总量的60%）和5种酶：神经氨酸酶、蛋白酶、核糖核酸酶、磷脂酶和ATP酶。该制剂在志愿者的初次免疫中已显示出安全性、无反应原性以及明确的免疫效力。
