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[口服霍乱化学疫苗在人体再接种有限对照试验中的反应原性和免疫效果]

[Reactogenicity and immunological effectiveness of an oral cholera chemical vaccine in a limited controlled experiment with human revaccination].

作者信息

Sumarokov A A, Ivanov N R, Lelikov V L, Dzhaparidze M N, Karaeva L T

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1978(12):87-92.

PMID:371293
Abstract

Oral cholera chemical vaccine in the doses tested (2 and 3 tablets) proved to be areactogenic, harmless and immunologically effective in a controlled limited trial in 150 volunteers. By the results of titration of specific antitoxins and vibriocidal antibodies in the blood serum, as well as of coproantibodies a dose of 2 tablets was chosen as the optimal one.

摘要

在对150名志愿者进行的对照性有限试验中,经测试剂量(2片和3片)的口服霍乱化学疫苗被证明是无反应原性、无害且具有免疫效力的。根据血清中特异性抗毒素和杀弧菌抗体以及粪便抗体的滴定结果,选择2片的剂量作为最佳剂量。

相似文献

1
[Reactogenicity and immunological effectiveness of an oral cholera chemical vaccine in a limited controlled experiment with human revaccination].[口服霍乱化学疫苗在人体再接种有限对照试验中的反应原性和免疫效果]
Zh Mikrobiol Epidemiol Immunobiol. 1978(12):87-92.
2
[A study of immunological efficacy of the oral chemical cholera vaccine on experimental animals].
Zh Mikrobiol Epidemiol Immunobiol. 1976 Nov(11):115-9.
3
[The determination of the optimal inoculation dose of an oral cholera chemical bivalent vaccine in a controlled experiment].[在一项对照实验中确定口服霍乱化学二价疫苗的最佳接种剂量]
Zh Mikrobiol Epidemiol Immunobiol. 1990 Dec(12):55-62.
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[The determination of the optimal inoculation dose of an oral cholera bivalent chemical vaccine in a controlled trial of the vaccination of children and adolescents].[在儿童和青少年霍乱双价化学疫苗接种对照试验中确定最佳接种剂量]
Zh Mikrobiol Epidemiol Immunobiol. 1993 Sep-Oct(5):55-60.
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Immunological memory after immunization with oral cholera B subunit--whole-cell vaccine in Swedish volunteers.瑞典志愿者口服霍乱B亚单位-全细胞疫苗免疫后的免疫记忆。
Vaccine. 1994 Sep;12(12):1078-82. doi: 10.1016/0264-410x(94)90176-7.
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[Study of the immunogenicity and immunological effectiveness of choleragen anatoxin (data from a controlled epidemiological experiment). II. The cahracterisitcs of choleragen anatoxin immunogenicity compared with corpuscular cholera vaccines administered by syringe and by using a jet injector].
Zh Mikrobiol Epidemiol Immunobiol. 1974 Nov(11):31-7.
7
[Reactogenicity and immunologic effectiveness of cholerogen-anatoxin. Feasibility of revaccination with cholerogen-anatoxin, determination of optimal doses and times for administration].[霍乱类毒素-类毒素的反应原性和免疫效力。霍乱类毒素-类毒素再接种的可行性、最佳剂量和接种时间的确定]
Zh Mikrobiol Epidemiol Immunobiol. 1976(12):85-91.
8
Response of man to infection with Vibrio cholerae. II. Protection from illness afforded by previous disease and vaccine.人类对霍乱弧菌感染的反应。II. 既往疾病和疫苗提供的疾病防护。
J Infect Dis. 1974 Oct;130(4):325-33. doi: 10.1093/infdis/130.4.325.
9
Safety and immunogenicity of oral killed whole cell recombinant B subunit cholera vaccine in Barranquilla, Colombia.口服灭活全细胞重组B亚单位霍乱疫苗在哥伦比亚巴兰基亚的安全性和免疫原性。
Bull Pan Am Health Organ. 1995 Dec;29(4):312-21.
10
[The characteristics of the reactogenicity and immunological activity of a new cholera bivalent chemical vaccine based on the results of controlled trials].[基于对照试验结果的新型霍乱双价化学疫苗的反应原性和免疫活性特征]
Zh Mikrobiol Epidemiol Immunobiol. 1991 Jul(7):55-8.

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Russian vaccines against especially dangerous bacterial pathogens.针对特别危险的细菌病原体的俄罗斯疫苗。
Emerg Microbes Infect. 2014 Dec;3(12):e86. doi: 10.1038/emi.2014.82. Epub 2014 Dec 17.
2
Oral vaccines for preventing cholera.用于预防霍乱的口服疫苗。
Cochrane Database Syst Rev. 2011 Mar 16;2011(3):CD008603. doi: 10.1002/14651858.CD008603.pub2.