Sumarokov A A, Ivanov N R, Lelikov V L, Dzhaparidze M N, Karaeva L T
Zh Mikrobiol Epidemiol Immunobiol. 1978(12):87-92.
Oral cholera chemical vaccine in the doses tested (2 and 3 tablets) proved to be areactogenic, harmless and immunologically effective in a controlled limited trial in 150 volunteers. By the results of titration of specific antitoxins and vibriocidal antibodies in the blood serum, as well as of coproantibodies a dose of 2 tablets was chosen as the optimal one.
在对150名志愿者进行的对照性有限试验中,经测试剂量(2片和3片)的口服霍乱化学疫苗被证明是无反应原性、无害且具有免疫效力的。根据血清中特异性抗毒素和杀弧菌抗体以及粪便抗体的滴定结果,选择2片的剂量作为最佳剂量。