deKernion J B, Lovrekovich L
Cancer Immunol Immunother. 1982;13(2):145-8. doi: 10.1007/BF00205316.
A suspension of heat-killed Aspergillus fumigatus mycelium inhibited the growth of a chemically-induced mouse bladder tumor (MBT). Tumor growth was inhibited when the mycelium was injected into mice in a mixture with the tumor cells, when injected into growing tumors, and when introduced IP at the time tumor cells were injected into the hind leg muscle. In the concentrations that affected tumor growth no toxicity of the fungus preparation was observed. The fungal suspension was more effective against MBT than a Corynebacterium parvum strain known to be a potent biologic response modifier. A significant increase in the number of mouse peritoneal exudate cells (PEC) was noted following inoculation with the mycelium. The induced PEC were cytotoxic to the tumor cells in vivo, suggesting that at least part of the tumor inhibition by the mycelium is host-mediated.
热灭活烟曲霉菌丝体悬液可抑制化学诱导的小鼠膀胱肿瘤（MBT）生长。当菌丝体与肿瘤细胞混合注入小鼠体内、注入生长中的肿瘤内以及在肿瘤细胞注入后腿肌肉时经腹腔注射引入时，肿瘤生长均受到抑制。在影响肿瘤生长的浓度下，未观察到真菌制剂的毒性。该真菌悬液对MBT的抑制作用比已知为强效生物反应调节剂的微小棒状杆菌菌株更有效。接种菌丝体后，小鼠腹腔渗出细胞（PEC）数量显著增加。诱导产生的PEC在体内对肿瘤细胞具有细胞毒性，这表明菌丝体对肿瘤的抑制作用至少部分是由宿主介导的。
