脑内注射短小棒状杆菌对小鼠脑肿瘤生长的影响。
Effect of intracerebral administration of Corynebacterium parvum on the growth of brain tumors in mice.
作者信息
Kiya K, Toge T, Harada K, Uozumi T, Hattori T
出版信息
Gan. 1981 Jun;72(3):446-50.
The effect of intracerebral administration of Corynebacterium parvum (C. parvum) on the growth of syngeneic brain tumors in C57BL/6 mice and the mechanism of its action were investigated. Mice were inoculated with 10(4) malignant glioma cells intracerebrally, and treated with various doses of C parvum on day 6 after tumor inoculation. The growth of tumors was significantly inhibited in proportion ot the dose of C. parvum. The cytotoxic activity of effector cells was enhanced when C. parvum was administered at the site of tumor inoculation. Significant cytotoxic activity was observed in the adherent cell fraction of brain mononuclear cells, while less cytotoxic activity was observed in the nonadherent cell fraction. These results indicate that activated intracranial macrophages may participate in the tumoricidal effect of intracerebral C. parvum administration.
研究了脑内注射短小棒状杆菌（C. parvum）对C57BL/6小鼠同基因脑肿瘤生长的影响及其作用机制。小鼠脑内接种10(4)个恶性胶质瘤细胞，并在肿瘤接种后第6天用不同剂量的C parvum进行治疗。肿瘤生长受到显著抑制，且与C. parvum的剂量成比例。当在肿瘤接种部位给予C. parvum时，效应细胞的细胞毒性活性增强。在脑单核细胞的贴壁细胞部分观察到显著的细胞毒性活性，而在非贴壁细胞部分观察到的细胞毒性活性较低。这些结果表明，活化的颅内巨噬细胞可能参与脑内注射C. parvum的杀肿瘤作用。
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