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一种在哺乳动物细胞的核仁中富集的保守组蛋白变体。

A conserved histone variant enriched in nucleoli of mammalian cells.

作者信息

Allis C D, Ziegler Y S, Gorovsky M A, Olmsted J B

出版信息

Cell. 1982 Nov;31(1):131-6. doi: 10.1016/0092-8674(82)90412-3.

DOI:10.1016/0092-8674(82)90412-3
PMID:6760982
Abstract

An antibody has been raised to Tetrahymena histone variant hv1 that specifically stains the macronucleus, but not the micronucleus, of Tetrahymena. This antiserum also stains small punctate regions in nucleoli of several mammalian cell lines. These observations suggest that this histone variant has been highly conserved in evolution and may be associated with transcribed sequences.

摘要

已制备出针对嗜热四膜虫组蛋白变体hv1的抗体，该抗体可特异性地对嗜热四膜虫的大核进行染色，而不对其小核染色。这种抗血清还可对几种哺乳动物细胞系核仁中的小斑点区域进行染色。这些观察结果表明，这种组蛋白变体在进化过程中高度保守，可能与转录序列相关。

相似文献

1
A conserved histone variant enriched in nucleoli of mammalian cells.一种在哺乳动物细胞的核仁中富集的保守组蛋白变体。
Cell. 1982 Nov;31(1):131-6. doi: 10.1016/0092-8674(82)90412-3.
2
Timing of the appearance of macronuclear-specific histone variant hv1 and gene expression in developing new macronuclei of Tetrahymena thermophila.嗜热四膜虫发育中新大核中巨核特异性组蛋白变体hv1的出现时间及基因表达
J Cell Biol. 1984 Jun;98(6):2107-17. doi: 10.1083/jcb.98.6.2107.
3
Sequence and properties of the message encoding Tetrahymena hv1, a highly evolutionarily conserved histone H2A variant that is associated with active genes.编码嗜热四膜虫hv1的信息序列及特性，hv1是一种与活跃基因相关的高度进化保守的组蛋白H2A变体。
Nucleic Acids Res. 1988 Jan 11;16(1):179-98. doi: 10.1093/nar/16.1.179.
4
hv1 is an evolutionarily conserved H2A variant that is preferentially associated with active genes.hv1是一种进化上保守的H2A变体，它优先与活跃基因相关联。
J Biol Chem. 1986 Feb 5;261(4):1941-8.
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Localization and expression of mRNA for a macronuclear-specific histone H2A variant (hv1) during the cell cycle and conjugation of Tetrahymena thermophila.嗜热四膜虫细胞周期和接合过程中，大核特异性组蛋白H2A变体（hv1）mRNA的定位与表达
Mol Cell Biol. 1988 Nov;8(11):4780-6. doi: 10.1128/mcb.8.11.4780-4786.1988.
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Temporal and spatial association of histone H2A variant hv1 with transcriptionally competent chromatin during nuclear development in Tetrahymena thermophila.嗜热四膜虫核发育过程中组蛋白H2A变体hv1与转录活性染色质的时空关联
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Drosophila has a single copy of the gene encoding a highly conserved histone H2A variant of the H2A.F/Z type.果蝇有一个编码H2A.F/Z型高度保守组蛋白H2A变体的基因的单拷贝。
Nucleic Acids Res. 1988 Aug 11;16(15):7487-97. doi: 10.1093/nar/16.15.7487.
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A novel histone variant localized in nucleoli of higher plant cells.
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Antibodies specific to acetylated histones document the existence of deposition- and transcription-related histone acetylation in Tetrahymena.针对乙酰化组蛋白的特异性抗体证明了四膜虫中存在与沉积和转录相关的组蛋白乙酰化。
J Cell Biol. 1989 May;108(5):1577-88. doi: 10.1083/jcb.108.5.1577.
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Proteolytic removal of core histone amino termini and dephosphorylation of histone H1 correlate with the formation of condensed chromatin and transcriptional silencing during Tetrahymena macronuclear development.在四膜虫大核发育过程中，核心组蛋白氨基末端的蛋白水解去除以及组蛋白H1的去磷酸化与浓缩染色质的形成和转录沉默相关。
Genes Dev. 1991 Sep;5(9):1601-10. doi: 10.1101/gad.5.9.1601.

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SUV39h-independent association of HP1 beta with fibrillarin-positive nucleolar regions.HP1β与原纤维蛋白阳性核仁区域的非SUV39h依赖性关联。
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Chromatin: linking structure and function in the nucleolus.染色质：核仁中结构与功能的联系
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Chromosome Res. 2003;11(8):787-95. doi: 10.1023/b:chro.0000005780.77785.5d.
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H2A.ZI, a new variant histone expressed during Xenopus early development exhibits several distinct features from the core histone H2A.H2A.ZI是非洲爪蟾早期发育过程中表达的一种新型变体组蛋白，它具有一些与核心组蛋白H2A不同的显著特征。
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