一种在哺乳动物细胞的核仁中富集的保守组蛋白变体。
A conserved histone variant enriched in nucleoli of mammalian cells.
作者信息
Allis C D, Ziegler Y S, Gorovsky M A, Olmsted J B
出版信息
Cell. 1982 Nov;31(1):131-6. doi: 10.1016/0092-8674(82)90412-3.
PMID:6760982
Abstract
An antibody has been raised to Tetrahymena histone variant hv1 that specifically stains the macronucleus, but not the micronucleus, of Tetrahymena. This antiserum also stains small punctate regions in nucleoli of several mammalian cell lines. These observations suggest that this histone variant has been highly conserved in evolution and may be associated with transcribed sequences.
摘要
已制备出针对嗜热四膜虫组蛋白变体hv1的抗体，该抗体可特异性地对嗜热四膜虫的大核进行染色，而不对其小核染色。这种抗血清还可对几种哺乳动物细胞系核仁中的小斑点区域进行染色。这些观察结果表明，这种组蛋白变体在进化过程中高度保守，可能与转录序列相关。
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