Shibuya T, Mak T W
Cell. 1982 Dec;31(2 Pt 1):483-93. doi: 10.1016/0092-8674(82)90141-6.
The genetic control of the susceptibility to early erythroleukemic induction by helper-independent Friend murine leukemia virus was determined to be due to the presence of a single dominant resistant locus. This locus, (termed Fv6), however, governs only resistance to early erythroleukemia, since other types of leukemias developed late in the resistant mice: myelomonocytic leukemia (approximately 70%), T-lymphoid leukemia (approximately 25%) and late erythroleukemia (approximately 10%). Data also indicated that mice with higher DBA/2 (resistant strain) genetic background had an increased frequency of myelomonocytic leukemias. Studies of the hemopoietic modulations indicated that mice that developed early or late erythroleukemia had dramatic increases in erythroid bursts, suggesting that the leukemic blocks are at the level of BFU-E or earlier. High levels of the granulocytic progenitor colonies were also found in mice with late erythroleukemia and myelomonocytic leukemia. Analysis of these leukemias indicate that they are multistage diseases.
非依赖辅助细胞的弗瑞德氏鼠白血病病毒诱导早期红白血病易感性的遗传控制被确定是由于存在一个单一的显性抗性基因座。然而，这个基因座（称为Fv6）仅控制对早期红白血病的抗性，因为在抗性小鼠中晚期会发生其他类型的白血病：骨髓单核细胞白血病（约70%）、T淋巴细胞白血病（约25%）和晚期红白血病（约10%）。数据还表明，具有较高DBA/2（抗性品系）遗传背景的小鼠骨髓单核细胞白血病的发生率增加。造血调节的研究表明，发生早期或晚期红白血病的小鼠红系爆增显著增加，这表明白血病阻滞发生在BFU-E水平或更早。在晚期红白血病和骨髓单核细胞白血病小鼠中也发现了高水平的粒细胞祖细胞集落。对这些白血病的分析表明它们是多阶段疾病。
