体外多步骤病毒诱导的白血病发生：一种确定髓母细胞恶性过程中三个步骤的模型描述。
Multistep virus-induced leukemogenesis in vitro: description of a model specifying three steps within the myeloblastic malignant process.
作者信息
Heard J M, Fichelson S, Sola B, Martial M A, Varet B, Levy J P
出版信息
Mol Cell Biol. 1984 Jan;4(1):216-20. doi: 10.1128/mcb.4.1.216-220.1984.
Abstract
A helper-independent Friend leukemia virus was used to infect bone marrow cultures. This virus induces myeloblastic leukemia in mice after a long latency period. Infection of the bone marrow cultures resulted in the in vitro production of myeloblastic leukemogenesis after a long latency period. Three steps were observed in the evolution of the infected cultures, and permanent cell lines were derived at each step. This allowed us to individualize three successive events in the course of the myeloblastic transformation: (i) an abnormal responsiveness to the physiological hormone granulo-macrophagic colony-stimulating factor, (ii) the acquisition of growth autonomy, and (iii) the acquisition of in vivo tumorigenicity.
摘要
一种辅助病毒非依赖型的弗瑞德白血病病毒被用于感染骨髓培养物。这种病毒在较长潜伏期后可诱发小鼠的成髓细胞白血病。骨髓培养物的感染在较长潜伏期后导致了体外成髓细胞白血病的发生。在受感染培养物的演变过程中观察到三个阶段，并且在每个阶段都获得了永久细胞系。这使我们能够明确成髓细胞转化过程中的三个连续事件：（i）对生理激素粒细胞-巨噬细胞集落刺激因子的异常反应性，（ii）获得生长自主性，以及（iii）获得体内致瘤性。
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