Crane F L, Crane H E, Sun I L, MacKellar W C, Grebing C, Löw H
J Bioenerg Biomembr. 1982 Dec;14(5-6):425-33. doi: 10.1007/BF00743068.
A study of NADH ferricyanide reductase activity in oriented vesicles or open ghosts of human and porcine erythrocytes shows that the dehydrogenase activity can have three types of orientation in the membrane. There is activity which responds only to acceptors and NADH exclusively on the inside face, or exclusively on the outer surface. There is also activity which requires exposure of both sides of the membrane and thus is transmembranous. The transmembrane activity is inhibited by insulin, whereas the internal and external enzymes do not respond to insulin. The transmembrane dehydrogenase can be a basis for proton transport in the plasma membrane.
一项关于人及猪红细胞定向囊泡或开放血影中NADH铁氰化物还原酶活性的研究表明，脱氢酶活性在膜中可有三种类型的取向。存在仅对内表面或仅对外表面的受体和NADH有反应的活性。也存在需要膜两侧都暴露因而为跨膜的活性。跨膜活性受胰岛素抑制，而内部和外部的酶对胰岛素无反应。跨膜脱氢酶可能是质膜中质子转运的基础。
