Dufour S, Pasqualini C, Kerdelhué B, Fontaine Y A
Neuropeptides. 1982 Dec;3(2):159-71. doi: 10.1016/0143-4179(82)90011-7.
Eel brain contains a factor which exhibited a complete cross-reaction in a radioimmunoassay (RIA) for mammalian luteinizing hormone-releasing hormone (LHRH) and which exhibited a behavior similar to that of synthetic mammalian LHRH on Sephadex G-25. Eel brains contained 920 +/- 135 pg of this LHRH-like immunoreactive factor (IR-LHRH); 75% of immunoreactivity was present in the di- and mes-encephalon, 21% in the telencephalon and 4% in the hind-brain. Thus, IR-LHRH in eel brain exhibited a much wider distribution than in mammalian brain. Pituitary also contained a large amount of IR-LHRH (304 +/- 69 pg) at a concentration even higher than in median hypothalamic lobe; this result is probably related to the fact that, in teleost, median eminence is included into the pituitary. An immunoreactive substance was also present in the blood. In conclusion, the lack of sexual development and the low gonadotropic function in the eel, are apparently not related to an absence of LHRH.
鳗鱼脑含有一种因子，该因子在针对哺乳动物促黄体生成激素释放激素（LHRH）的放射免疫分析（RIA）中表现出完全交叉反应，并且在葡聚糖凝胶G - 25上表现出与合成哺乳动物LHRH相似的行为。鳗鱼脑含有920±135 pg这种类似LHRH的免疫反应性因子（IR - LHRH）；75%的免疫反应性存在于间脑和中脑，21%存在于端脑，4%存在于后脑。因此，鳗鱼脑中的IR - LHRH分布比哺乳动物脑广泛得多。垂体也含有大量的IR - LHRH（304±69 pg），其浓度甚至高于下丘脑中间叶；这一结果可能与硬骨鱼中正中隆起包含在垂体中的事实有关。血液中也存在一种免疫反应性物质。总之，鳗鱼缺乏性发育和低促性腺功能显然与缺乏LHRH无关。
