先天性巨结肠症患者结肠中血管活性肠肽的免疫组织化学研究。
An immunohistochemical investigation of vasoactive intestinal polypeptide in the colon of patients with Hirschsprung's disease.
作者信息
Tsuto T, Okamura H, Fukui K, Obata H L, Terubayashi H, Iwai N, Majima S, Yanaihara N, Ibata Y
出版信息
Neurosci Lett. 1982 Dec 23;34(1):57-62. doi: 10.1016/0304-3940(82)90092-1.
The distribution of vasoactive intestinal polypeptide (VIP) in the colon of patients with Hirschsprung's disease was investigated by the peroxidase-antiperoxidase (PAP) immunohistochemical method. Three colonic segments, ganglionic, oligoganglionic and aganglionic, were stained by the unlabeled antibody enzyme method. VIP immunoreactive nerve cell bodies, nerve fibers and nerve endings were distributed throughout the ganglionic and oligoganglionic segments. In contrast, the aganglionic segment contained no VIP nerve endings and the number of fibers was reduced. These differences are thought to be a cause of constriction of the colon in Hirschsprung's disease and VIP neurons are therefore believed to participate in the relaxation of smooth muscle.
采用过氧化物酶-抗过氧化物酶（PAP）免疫组织化学方法，研究了先天性巨结肠患者结肠中血管活性肠肽（VIP）的分布情况。用未标记抗体酶法对结肠的三个节段，即有神经节段、神经节减少段和无神经节段进行染色。VIP免疫反应性神经细胞体、神经纤维和神经末梢分布于整个有神经节段和神经节减少段。相比之下，无神经节段不含VIP神经末梢，且纤维数量减少。这些差异被认为是先天性巨结肠患者结肠狭窄的原因，因此VIP神经元被认为参与了平滑肌的舒张。
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