Jiménez López A, Olmos Martínez J M, García Palomo J D, De Dios Martín B, Pedraz García M J, Lorente Toledano F
Allergol Immunopathol (Madr). 1982 Sep-Oct;10(5):353-9.
Monocytes derived from peripheral blood of patients with rheumatoid arthritis (RA) had a marked defect in their chemotactic and phagocytic activity. The chemotactic defect resides at a cellular level, while the phagocytic defect is serum-dependent. Both defects could be of importance in the pathogenicity of RA and the susceptibility to infection such patients show. Finally, monocytes were found to have a negative influence over spontaneous cytotoxicity mediated by T lymphocytes.
类风湿关节炎（RA）患者外周血来源的单核细胞在趋化和吞噬活性方面存在明显缺陷。趋化缺陷存在于细胞水平，而吞噬缺陷则依赖于血清。这两种缺陷可能在RA的发病机制以及此类患者表现出的感染易感性中具有重要意义。最后，发现单核细胞对T淋巴细胞介导的自发细胞毒性有负面影响。
