Verani R, Dan M
Am J Nephrol. 1982;2(6):316-20. doi: 10.1159/000166668.
A patient with membranous glomerulonephritis (MGN) presented with recurrent disease after renal transplantation. The disease on the original and the transplanted kidney was characterized by diffuse subepithelial electron-dense deposits on the glomerular basement membranes. Including this case, 23 cases of MGN have been reported in renal transplants, of which 8 are 'recurrent' and 15 are 'de novo'. This incidence of 'de novo' MGN makes it the most common type of 'de novo' glomerulonephritis in renal transplants. Survey of clinical and morphological features of the cases of both the 'de novo' and the 'recurrent' disease failed to identify a specific cause of the MGN. Hypothetically, immunosuppression in transplanted patients may lower the antibody response to levels that favor the development of membranous glomerulonephritis.
一名膜性肾小球肾炎（MGN）患者在肾移植后出现疾病复发。原肾和移植肾的疾病特征均为肾小球基底膜上弥漫性的上皮下电子致密沉积物。包括该病例在内，肾移植中已报道23例MGN，其中8例为“复发型”，15例为“新发型”。这种新发MGN的发生率使其成为肾移植中最常见的“新发”肾小球肾炎类型。对“新发”和“复发”疾病病例的临床和形态学特征进行调查，未能确定MGN的具体病因。据推测，移植患者的免疫抑制可能会将抗体反应降低到有利于膜性肾小球肾炎发展的水平。
