Alvarez F, Bernard O, Alagille D
Arch Fr Pediatr. 1982 Dec;39 Suppl 2:767-70.
An immunoperoxidase study of HBsAg and HBcAg was carried out on liver biopsies of 30 children with chronic hepatitis or idiopathic cirrhosis. Presence of HBsAg and HBcAg occurred only in children who were HBsAg positive in their serum. The number of cytoplasmic HBsAg positive hepatocytes appears higher in children whose liver disease is histologically less severe. The number of hepatocytes with nuclear HBcAg seems directly related to the presence or absence of HBeAg in the serum. Those results are in agreement with previously published observations suggesting that the host's immune response is an important factor of the severity of the liver disease in hepatitis B infections.
对30例慢性肝炎或特发性肝硬化患儿的肝活检组织进行了乙肝表面抗原（HBsAg）和乙肝核心抗原（HBcAg）的免疫过氧化物酶研究。HBsAg和HBcAg仅在血清HBsAg阳性的患儿中出现。在组织学上肝脏疾病较轻的患儿中，细胞质HBsAg阳性肝细胞的数量似乎更多。细胞核HBcAg阳性的肝细胞数量似乎与血清中HBeAg的有无直接相关。这些结果与先前发表的观察结果一致，表明宿主的免疫反应是乙型肝炎感染中肝脏疾病严重程度的一个重要因素。
