Cotrozzi G, Matteini M, Relli P, Lazzari T, Bufalini G N
Boll Soc Ital Biol Sper. 1982 Nov 30;58(22):1446-50.
OGTT was used to clarify the problem of hyperinsulinism and insulin resistance previously investigated by us in PCOS, using the tolbutamide test. The results of this latter investigation were in agreement with the previous found by us and with the similar already reported by other Authors. 26 women (7 obese), aged 14-34 years, affected by PCOS, were studied. The diagnosis of PCOS was made using clinical, hormonal, radiologic and echographic criteria. 16 age matched healthy women were used as controls. Glucose and insulin curves, glucose (GA) and insulin (IA) response areas and IA/GA ratio (insulin resistance in dex-IRI-) were studied by OGTT. Blood insulin values of patients resulted significantly more elevated than that of controls at any point of the curve and more significantly elevated were decreasing values. Mean values of insulin peaks, of insulin areas and of IRI resulted more elevated than that of controls. The presence of both an hyperinsulinism and an insulin resistance in PCOS seems therefore evident. A correlation was found between IRI values and plasma testosterone levels in non obese patients with increased urinary 17-ketosteroid output. A relationship between hyperandrogenism on one hand and hyperinsulinism and insulin resistance on the other is suggested.
口服葡萄糖耐量试验（OGTT）用于明确我们之前通过甲苯磺丁脲试验在多囊卵巢综合征（PCOS）中所研究的高胰岛素血症和胰岛素抵抗问题。后一项研究的结果与我们之前的发现一致，也与其他作者已报道的类似结果相符。对26名年龄在14 - 34岁、患有PCOS的女性（其中7名肥胖）进行了研究。PCOS的诊断依据临床、激素、放射学和超声检查标准。选取16名年龄匹配的健康女性作为对照。通过OGTT研究了血糖和胰岛素曲线、血糖（GA）和胰岛素（IA）反应面积以及IA/GA比值（右旋胰岛素抵抗指数中的胰岛素抵抗）。患者的血胰岛素值在曲线的任何一点均显著高于对照组，且下降值升高更为显著。胰岛素峰值、胰岛素面积和胰岛素抵抗指数的平均值均高于对照组。因此，PCOS中高胰岛素血症和胰岛素抵抗的存在似乎很明显。在尿17 - 酮类固醇排出量增加的非肥胖患者中，发现胰岛素抵抗指数值与血浆睾酮水平之间存在相关性。提示一方面高雄激素血症与另一方面高胰岛素血症和胰岛素抵抗之间存在关联。
