Matteini M, Cotrozzi G, Bufalini G N, Relli P, Lazzari T
Boll Soc Ital Biol Sper. 1982 Nov 30;58(22):1455-60.
The aim of this research was to study both insulin secretion and insulin resistance index (IRI) in seventeen females, aged 16-30, affected by polycystic ovarian syndrome. The diagnosis was made using clinical, hormonal, radiological and echographic criteria. Eight healthy women, carefully matched with our patients for age and for statistical obesity incidence, were studied as controls. Both glycemic and insulinemic curves, areas, insulinemic/glycemic area ratio (IRI) were studied by tolbutamide test (1 g i.v.). Areas were assessed by planimeter, blood glucose by Trinder method, blood insulin by a RIA method, statistical study by t Student test and correlation coefficients. These latter were determined by comparing individual plasma testosterone, FSH, LH and LH/FSH ratio values together with urinary total 17-ketosteroid and delta HEA output values on the one hand and insulin areas and IRI values on the other. Increased glycemic areas, insulinemic peaks and areas, associated with markedly increased IRI values, were observed in the patients. A correlation exists between hyperinsulinism, insulin resistance on the one hand and increased urinary androgens output on the other. delta HEA resulted particularly increased over other androgenic fractions.
本研究旨在对17名年龄在16至30岁之间、患有多囊卵巢综合征的女性的胰岛素分泌和胰岛素抵抗指数（IRI）进行研究。诊断采用临床、激素、放射学和超声检查标准。选取8名年龄和统计肥胖发生率与我们的患者仔细匹配的健康女性作为对照进行研究。通过甲苯磺丁脲试验（静脉注射1克）研究血糖和胰岛素曲线、面积、胰岛素/血糖面积比（IRI）。面积用求积仪评估，血糖用Trinder法测定，血胰岛素用放射免疫分析法测定，采用t检验和相关系数进行统计学研究。后者通过比较个体血浆睾酮、促卵泡激素（FSH）、促黄体生成素（LH）和LH/FSH比值以及尿总17 - 酮类固醇和δ - 硫酸脱氢表雄酮（delta HEA）输出值与胰岛素面积和IRI值来确定。在患者中观察到血糖面积、胰岛素峰值和面积增加，同时IRI值显著升高。高胰岛素血症、胰岛素抵抗与尿雄激素输出增加之间存在相关性。与其他雄激素组分相比，delta HEA升高尤为明显。
