正常血压和高血压妊娠中的肾素-血管紧张素-醛固酮系统及肾上腺素能系统

Renin angiotensin aldosterone system and adrenergic system in normotensive and hypertensive pregnancy.

作者信息

Coevoet B, Fievet P, Comoy E, Legrand F, Makdassi R, Verhoest P, Boulanger J C, Fournier A

出版信息

Clin Exp Hypertens B. 1982;1(4):479-91. doi: 10.3109/10641958209009620.

DOI:10.3109/10641958209009620

Abstract

We have measured simultaneously plasma renin activity (PRA), aldosterone and catecholamines in the plasma of 3 groups of pregnant women after the 20th week: group 1 of 16 normotensive controls, group II of 17 women with rest responding hypertension (RRH), group III of 18 women with permanent hypertension (PIH). All the patients were ambulatory on a normal salt diet. PRA was significantly higher in the RRH than in the control and PIH groups (15,8 +/- 2,3ng/ml/l versus 6,7 +/- 0,5 and 8,9 +/- 0,9 respectively). Plasma epinephrine (PE) and norepinephrine (PNE) were significantly higher in the PIH than in the control and RRH groups (respectively 135 +/- 28 pg/ml versus 56 +/- 13 and 63 +/- 17 for PE and 387 +/- 91 versus 206 +/- 32 and 200 +/- 47 pg/ml for PNE). In the PIH group there was a negative correlation between PRA and blood uric acid. It is concluded that the adrenic system is activated in PIH whereas the renin angiotensin system is activated in RRH of pregnancy.

摘要

我们在妊娠20周后，对3组孕妇同时测定了血浆肾素活性（PRA）、醛固酮和血浆儿茶酚胺：第1组为16名血压正常的对照组，第II组为17名休息时反应性高血压（RRH）的孕妇，第III组为18名持续性高血压（PIH）的孕妇。所有患者均按正常盐饮食进行动态观察。RRH组的PRA显著高于对照组和PIH组（分别为15.8±2.3ng/ml/l，而对照组为6.7±0.5，PIH组为8.9±0.9）。PIH组的血浆肾上腺素（PE）和去甲肾上腺素（PNE）显著高于对照组和RRH组（PE分别为135±28pg/ml，而对照组为56±13，RRH组为63±17；PNE分别为387±91pg/ml，而对照组为206±32，RRH组为200±47pg/ml）。在PIH组中，PRA与血尿酸之间存在负相关。结论是，PIH时肾上腺系统被激活，而妊娠RRH时肾素-血管紧张素系统被激活。