Nagao M, Fujita Y, Sugimura T, Kosuge T
IARC Sci Publ. 1986(70):283-91.
Methylglyoxal was found to induce mutations in Salmonella typhimurium strains TA100, TA102 and TA104, gene conversion in Saccharomyces cerevisiae strain D7, and diphtheria toxin resistance mutation in Chinese hamster lung cells. Methylglyoxal was detected in coffee, whiskey, a soft drink, toasted bread and soy sauce. The mutagenicity of methylglyoxal was suppressed by sulfite, cysteine, glutathione and dithiothreitol, and enhanced by hydrogen peroxide. Methylglyoxal induced sarcomas in rats at the site of its subcutaneous injection.
已发现甲基乙二醛可在鼠伤寒沙门氏菌TA100、TA102和TA104菌株中诱发突变，在酿酒酵母D7菌株中诱发基因转换，并在中国仓鼠肺细胞中诱发白喉毒素抗性突变。在咖啡、威士忌、一种软饮料、烤面包和酱油中检测到了甲基乙二醛。甲基乙二醛的致突变性受到亚硫酸盐、半胱氨酸、谷胱甘肽和二硫苏糖醇的抑制，并受到过氧化氢的增强。甲基乙二醛在大鼠皮下注射部位诱发肉瘤。
