具有弱P抗原的红细胞的异常糖脂组成。

Abnormal glycolipid composition of erythrocytes with a weak P antigen.

作者信息

Kundu S K, Steane S M, Bloom J E, Marcus D M

出版信息

Vox Sang. 1978 Sep;35(3):160-7. doi: 10.1111/j.1423-0410.1978.tb02916.x.

DOI:10.1111/j.1423-0410.1978.tb02916.x

Abstract

The erythrocytes of a normal man were agglutinated more weakly than normal cells by several anti-P1PPK sera, and exhibited a decreased capacity to absorb these antibodies. Analysis of his erythrocyte glycosphingolipids revealed that the globoside (P antigen) content was less than 25% of normal, and trihexosyl ceramide (the PK antigen) was 30-40% of normal. The ganglioside content of his erythrocytes was approximately four times normal and sialosylparagloboside was increased about sixfold. It appears that his erythrocytes was unable to synthesize normal quantities of trihexosyl ceramide, and that these serological and chemical features constitute a new phenotype in the P blood group system.

摘要

几名抗P1PPK血清使一名正常男性的红细胞凝集程度比正常细胞弱，并且吸收这些抗体的能力降低。对其红细胞糖鞘脂的分析显示，红细胞糖苷脂（P抗原）含量不到正常水平的25%，三己糖神经酰胺（PK抗原）为正常水平的30 - 40%。其红细胞神经节苷脂含量约为正常的四倍，唾液酸副红细胞糖苷脂增加约六倍。看来他的红细胞无法合成正常量的三己糖神经酰胺，并且这些血清学和化学特征构成了P血型系统中的一种新表型。