Williams P L
Am Ind Hyg Assoc J. 1982 Nov;43(11):799-810. doi: 10.1080/15298668291410602.
Pentachlorophenol (PCP) is used primarily as a wood preservative. It can be absorbed into the body by all the routes of occupational exposure. It causes local irritation to the eyes and nose, as well as systemic effects that result from its ability to uncouple mitochondrial oxidative phosphorylation. Also, it is fetotoxic and teratogenic during early gestation. Commercial PCP is contaminated with chlorinated dioxins and dibenzofurans, tetrachlorophenols, and hydroxychlorodiphenyl ethers. Some of these impurities are capable of causing chloracne and chronic liver damage. Several areas in PCP's toxicological profile, such as carcinogenesis and mutagenesis, are incomplete. With regard to occupational exposures, precautions should be taken to avoid direct contact and air levels should be kept within acceptable levels.
五氯苯酚（PCP）主要用作木材防腐剂。它可通过所有职业接触途径被人体吸收。它会对眼睛和鼻子造成局部刺激，还会因其使线粒体氧化磷酸化解偶联的能力而产生全身影响。此外，在妊娠早期它具有胚胎毒性和致畸性。商用五氯苯酚被氯代二噁英、二苯并呋喃、四氯苯酚和羟基氯代二苯醚污染。其中一些杂质能够导致氯痤疮和慢性肝损伤。五氯苯酚毒理学概况中的几个方面，如致癌作用和诱变作用，尚不完整。对于职业接触，应采取预防措施避免直接接触，空气浓度应保持在可接受水平之内。
