Hryhorczuk D O, Wallace W H, Persky V, Furner S, Webster J R, Oleske D, Haselhorst B, Ellefson R, Zugerman C
Department of Preventive Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.
Environ Health Perspect. 1998 Jul;106(7):401-8. doi: 10.1289/ehp.98106401.
Pentachlorophenol (PCP) is a pesticide that was once widely used for wood preservation. Commercial PCP contained impurities including higher chlorinated dibenzo-p-dioxins (CDDs) and chlorinated dibenzofurans (CDFs). We investigated the effects of occupational exposure to PCP and its CDD and CDF contaminants on the skin, liver, porphyrin metabolism, and central and peripheral nervous systems. In 1986 we conducted a medical survey of 366 workers who had been engaged in the production of PCP at a single plant between 1938 and 1978. The referent group consisted of 303 workers from the same plant who were not exposed to these or related compounds. Exposure was determined from computerized personnel records. The medical survey included an administered questionnaire, medical record review, physical examination by dermatologists, internists, and neurologists, and analysis of 24-hr urine for quantitative porphyrins among other tests. In this paper we present the results of analyses of the general health, chloracne, and porphyrin metabolism end points. The general health status of PCP workers was similar to unexposed workers, but 17.8% of PCP workers had evidence of current or past chloracne. PCP workers with chloracne had significantly higher mean urinary excretion of coproporphyrins (117. 0 vs. 90.6 microg/24 hr) than unexposed workers after controlling for potential confounders. Workers with chloracne who had worked with both PCP and polychlorinated biphenyls had significantly higher mean urinary excretions of hepta-, penta-, and coproporphyrins than unexposed workers. We conclude that occupational exposure to PCP is associated with chloracne and biochemical abnormalities which may persist years after exposure.
五氯苯酚（PCP）是一种曾被广泛用于木材防腐的杀虫剂。商用五氯苯酚含有杂质，包括高氯代二苯并 - 对 - 二恶英（CDDs）和氯代二苯并呋喃（CDFs）。我们研究了职业性接触五氯苯酚及其CDD和CDF污染物对皮肤、肝脏、卟啉代谢以及中枢和外周神经系统的影响。1986年，我们对1938年至1978年间在一家工厂从事五氯苯酚生产的366名工人进行了医学调查。对照组由来自同一工厂的303名未接触这些或相关化合物的工人组成。接触情况通过计算机化的人事记录确定。医学调查包括一份 administered问卷、病历审查、皮肤科医生、内科医生和神经科医生进行的体格检查，以及对24小时尿液进行定量卟啉分析等测试。在本文中，我们展示了对总体健康、氯痤疮和卟啉代谢终点分析的结果。五氯苯酚工人的总体健康状况与未接触工人相似，但17.8%的五氯苯酚工人有当前或过去患氯痤疮的证据。在控制了潜在混杂因素后，患有氯痤疮的五氯苯酚工人的粪卟啉平均尿排泄量（117.0对90.6微克/24小时）显著高于未接触工人。同时接触五氯苯酚和多氯联苯且患有氯痤疮的工人，其七卟啉、五卟啉和粪卟啉的平均尿排泄量显著高于未接触工人。我们得出结论，职业性接触五氯苯酚与氯痤疮和生化异常有关，这些异常可能在接触后持续数年。 （注：administered此处似拼写有误，可能是administered，意为“ administered问卷”不太准确，推测是“问卷调查”之类意思，但按要求未修改原文表述 ）
