Cifone M G, Alesse E, Ianni G, Continenza M A, Conti P
Boll Soc Ital Biol Sper. 1982 Dec 30;58(24):1666-71.
In the present work it has been tested if associations of indomethacin or aspirin with diflunisal or sodium salicylate block PGI2 release from gastric mucosa less than the administration of the compounds alone. PGI2 production was determined on aliquots of incubated mucosal strips, tested for ADP-induced aggregation of human platelet rich plasma. The obtained data indicate that PGI2 generation found in rats treated with indomethacin or aspirin associated with diflunisal or sodium salicylate was higher than that found in rats treated with indomethacin or aspirin alone. This effect may be likely explained by competition between salicylates and other non steroidal anti-inflammatory drugs for binding sites on PG-synthetase and plasma proteins.
在本研究中，已对吲哚美辛或阿司匹林与二氟尼柳或水杨酸钠联合使用时，是否比单独使用这些化合物更不易阻断胃黏膜释放前列环素（PGI2）进行了测试。通过对孵育的黏膜条等分试样测定PGI2生成量，并检测其对富含人血小板血浆中ADP诱导的聚集作用。所得数据表明，用吲哚美辛或阿司匹林与二氟尼柳或水杨酸钠联合处理的大鼠中，PGI2生成量高于单独用吲哚美辛或阿司匹林处理的大鼠。这种效应可能是由于水杨酸盐与其他非甾体抗炎药竞争PG合成酶和血浆蛋白上的结合位点所致。
