未夹闭肾性高血压大鼠对花生四烯酸和前列腺素的降压反应减弱
Attenuated depressor response to arachidonic acid and prostaglandins in unclipped renal hypertensive rats.
作者信息
Ten Berg R G, De Jong W, Nijkamp F P
出版信息
Br J Pharmacol. 1980 Mar;68(3):519-24. doi: 10.1111/j.1476-5381.1980.tb14567.x.
Abstract
1 In renal hypertensive rats (one-clip, two-kidney type) blood pressure returned to a normotensive level within 24 h after the removal of the renal artery clip (unclipping). 2 The decrease in blood pressure caused by intravenous administration of arachidonic acid, prostaglandin E2 and prostaglandin I2 was significantly reduced in these unclipped rats. 3 The hypotensive response to bradykinin and acetylcholine was the same in unclipped rats and in control rats. 4 Nephrectomy abolished the difference in blood pressure response to arachidonic acid and the two prostaglandins between unclipped and control rats. 5 An enhanced secretion of renin, as indicated by the absence of an increase in plasma renin activity, did not seem to be involved in the attenuated blood pressure response to arachidonic acid in unclipped rats.
摘要
- 在肾性高血压大鼠（单夹双肾型）中，移除肾动脉夹（解除夹闭）后24小时内血压恢复至正常血压水平。2. 在这些解除夹闭的大鼠中，静脉注射花生四烯酸、前列腺素E2和前列腺素I2所引起的血压下降显著降低。3. 解除夹闭的大鼠和对照大鼠对缓激肽和乙酰胆碱的降压反应相同。4. 肾切除术消除了解除夹闭的大鼠和对照大鼠在对花生四烯酸和两种前列腺素的血压反应上的差异。5. 血浆肾素活性未增加表明肾素分泌增强似乎与解除夹闭的大鼠对花生四烯酸的血压反应减弱无关。
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