ten Berg R G, de Jong W
Pflugers Arch. 1979 Jun 12;380(2):133-7. doi: 10.1007/BF00582148.
Moderate or severe hypertension was induced in rats by application of a clip 0.25 or 0.20 mm internal diameter) to the left renal artery leaving the contralateral kidney intact. Removal of the clip 6, 13 or 24 days after the induction of the hypertension was followed by a rapid decrease in blood pressure. A near normotensive level was reached after 2--6 h. Reapplication of the clip to the unclipped renal artery after 1 day caused an enhanced blood pressure response. The preoperative hypertensive levels were reached within 2 h. This enhanced response was related to the level of blood pressure before the removal of the clip. Lengthening the interval between removal and reapplication of the clip gradually reduced the enhanced response of blood pressure, which had disappeared 8 days after the removal of the clip. Reapplication of the clip to the contralateral renal artery was not followed by an enhanced response in rats with previous moderate or severe hypertension.
通过将内径为0.25或0.20毫米的夹子夹在左肾动脉上而使大鼠诱发中度或重度高血压，对侧肾脏保持完整。在高血压诱发后6、13或24天移除夹子，随后血压迅速下降。2至6小时后达到接近正常血压水平。在1天后将夹子重新夹在未夹闭的肾动脉上会引起血压反应增强。术前高血压水平在2小时内达到。这种增强反应与移除夹子前的血压水平有关。延长移除和重新夹闭夹子之间的间隔会逐渐降低血压增强反应，该反应在移除夹子8天后消失。对于先前有中度或重度高血压的大鼠，将夹子重新夹在对侧肾动脉上不会出现增强反应。
