Muller J Y, Kaplan C, Betuel H, Bignon J D, Fauchet R, Gluckman J C, Soulillou J P, Thibault P
Nouv Presse Med. 1982 Dec 11;11(50):3697-701.
In a retrospective study involving 24 transplantation centres and 858 cadaveric kidney recipients, a number of transfusion factors affecting transplant survival were identified. The best results were observed with the most intensive transfusion schedules including at least one transfusion per month. The optimal number of transfusions varied from 6 to 20. However, it was impossible to determine whether a minimal interval was required between the last perfusion and transplantation, or whether the effect of each transfusion was limited in time. Qualitatively, it appeared that whole blood and packed red cells gave better results than leucocyte-deprived blood. Moreover, fresh blood taken less than 3 days before the transfusion clearly proved more effective than blood stored for more than 5 days. All this suggests that live leucocytes and platelets may be important factors. The mechanism by which blood transfusions improve the outcome of kidney transplants remains unknown.
在一项涉及24个移植中心和858名尸体肾移植受者的回顾性研究中，确定了一些影响移植存活的输血因素。采用最密集的输血方案（包括每月至少输血一次）时观察到了最佳结果。最佳输血量在6至20次之间。然而，无法确定在最后一次灌注和移植之间是否需要最短间隔时间，或者每次输血的效果是否有时间限制。从质量上看，全血和红细胞悬液似乎比去白细胞血液效果更好。此外，输血前不到3天采集的新鲜血液明显比储存超过5天的血液更有效。所有这些表明活白细胞和血小板可能是重要因素。输血改善肾移植结果的机制尚不清楚。
