阿苯达唑治疗钩虫感染的临床试验。

Clinical trial of albendazole in hookworm infection.

作者信息

Viravan C, Migasena S, Bunnag D, Harinasuta T

出版信息

Southeast Asian J Trop Med Public Health. 1982 Dec;13(4):654-7.

Abstract

A clinical trial of albendazole (Zentel R) was carried out at the Hospital for Tropical Diseases in 1981. Thirty-five patients with hookworm infection were divided into 2 groups A, B and treated with a single dose of albendazole 400 mg and 600 mg respectively. The age of the patients ranged from 12 to 66 years and their weights ranged from 25 to 62 kilograms. Concentration and Stoll egg count methods were done at pretreatment, day 14 and day 21. At each interval two aliquots from each of the two faecal specimens were collected. The geometrical mean of EPG in Group A and B were 5406 and 5617 respectively. The cure rate in patients with less than 5000 EPG was 75% on day 21 in Group A and 67% in Group B. The mean percentage egg reduction was 95% in Group A and 99% in Group B. In patients with a higher egg out-put, the cure rate on day 21 was 50% in Group A and 29% in Group B. The mean percentage egg reduction was 91% in Group A and 93% in B. The side effects were mild and transient.

摘要

1981年，在热带病医院开展了一项阿苯达唑（肠虫清）的临床试验。35名钩虫感染患者被分为A、B两组，分别接受400毫克和600毫克单剂量阿苯达唑治疗。患者年龄在12至66岁之间，体重在25至62千克之间。在治疗前、第14天和第21天进行浓度和斯托尔虫卵计数法检测。在每个时间间隔，从两份粪便标本中各采集两份等分样本。A组和B组每克粪便虫卵数（EPG）的几何平均值分别为5406和5617。EPG低于5000的患者在第21天的治愈率，A组为75%，B组为67%。A组虫卵减少的平均百分比为95%，B组为99%。对于虫卵排出量较高的患者，第21天的治愈率A组为50%，B组为29%。A组虫卵减少的平均百分比为91%，B组为93%。副作用轻微且短暂。