IgA 缺乏症中抗兔 IgM 的频繁出现。

Frequent occurrence of anti-rabbit IgM in IgA deficiency.

作者信息

Truedsson L, Axelsson U, Laurell A B

出版信息

Acta Pathol Microbiol Immunol Scand C. 1982 Dec;90(6):315-20. doi: 10.1111/j.1699-0463.1982.tb01456.x.

DOI:10.1111/j.1699-0463.1982.tb01456.x

Abstract

Analysis of IgA deficient sera revealed impaired hemolysis of sensitized sheep erythrocytes when tested by a hemolysis in gel (HIG) assay developed for detection of complement deficiencies. All sera were normal in a test for the alternative pathway. The impaired hemolysis was not related to complement aberrations but was caused by antibodies to rabbit IgM, demonstrated in 14 of 21 IgA deficient sera, by use of HIG technique and by agglutination. The presence of these antibodies was not related to age, sex or disease. One serum was further examined and the antibodies were shown to be of IgG class.

摘要

对IgA缺陷血清的分析显示，在用于检测补体缺陷的凝胶溶血（HIG）试验中检测时，致敏绵羊红细胞的溶血功能受损。在替代途径检测中，所有血清均正常。溶血功能受损与补体异常无关，而是由兔IgM抗体引起的，通过HIG技术和凝集试验在21份IgA缺陷血清中的14份中得到证实。这些抗体的存在与年龄、性别或疾病无关。对一份血清进行了进一步检查，结果显示这些抗体属于IgG类。