Kobayashi T, Sawano S, Itoh T, Sugimoto T, Tanaka T, Suwa S
Endocrinol Jpn. 1981 Aug;28(4):429-33. doi: 10.1507/endocrj1954.28.429.
The presence of complement-fixing islet-cell antibodies (CF-ICA) and islet-cell antibodies (ICA) was examined in 355 patients with different types of diabetes mellitus in the Japanese population by an indirect immunofluorescence test (IFT). The overall prevalence of ICA, which were stained as a homogenous cytoplasmic fluorescence in islet cells, was 7 per cent (5/67) in insulin-dependent (Type I) diabetics, 4 per cent (6/137) in noninsulin-dependent (Type II) diabetics treated with insulin and 2 per cent (1/58) in Type II diabetics treated with oral hypoglycemic agents. None of 84 Type II diabetics receiving diet alone and 9 diabetics associated with chronic pancreatitis had ICA. CF-ICA, which were stained as a "ring-shaped" fluorescence in a part of the cytoplasma, were demonstrated in 5 out of 12 cases (42%) whose sera possessed ICA. The lower prevalence and remarkably shorter persistence of ICA and CF-ICA in Japanese diabetics than those observed in Caucasian diabetics may be explained by the heterogenous immunological response in different races or possible heterogeneity of Type I diabetics.
通过间接免疫荧光试验（IFT），对355名日本不同类型糖尿病患者进行了补体结合胰岛细胞抗体（CF - ICA）和胰岛细胞抗体（ICA）检测。胰岛细胞中呈现均匀胞质荧光染色的ICA总体患病率在胰岛素依赖型（I型）糖尿病患者中为7%（5/67），在接受胰岛素治疗的非胰岛素依赖型（II型）糖尿病患者中为4%（6/137），在接受口服降糖药治疗的II型糖尿病患者中为2%（1/58）。84名仅接受饮食治疗的II型糖尿病患者和9名合并慢性胰腺炎的糖尿病患者均未检测到ICA。在血清中存在ICA的12例患者中有5例（42%）检测到CF - ICA，其在部分细胞质中呈现“环形”荧光染色。与白种人糖尿病患者相比，日本糖尿病患者中ICA和CF - ICA的患病率较低且持续时间明显较短，这可能是由于不同种族的免疫反应异质性或I型糖尿病可能存在的异质性所致。
