Bottazzo G F, Dean B M, Gorsuch A N, Cudworth A G, Doniach D
Lancet. 1980 Mar 29;1(8170):668-72.
Evidence is presented for the existence of a separate species of islet-cell antibodies which fix complement. Investigations in type I diabetics, non-diabetic polyendocrine patients, and unaffected first-degree relatives of type I diabetic probands show that the complement-fixing islet-cell antibodies are more closely related to the onset of clinical disease than the conventional islet-cell antibody, and they tend to disappear more rapidly. The complement-fixing antibodies may reflect damage of pancreatic beta cells more selectively and may be preferable to the conventional antibody as a serological marker for studying the natural history of type I diabetes.
有证据表明存在一种能固定补体的胰岛细胞抗体的独立种类。对I型糖尿病患者、非糖尿病多内分泌腺病患者以及I型糖尿病先证者的未患病一级亲属的研究表明，与传统胰岛细胞抗体相比，能固定补体的胰岛细胞抗体与临床疾病的发作关系更为密切，且它们往往消失得更快。能固定补体的抗体可能更有选择性地反映胰腺β细胞的损伤，并且作为研究I型糖尿病自然史的血清学标志物，可能比传统抗体更具优势。
