衰老过程中脂褐素色素在人脑中的积累。

Lipofuscin pigment accumulation in human brain during aging.

作者信息

Goyal V K

出版信息

Exp Gerontol. 1982;17(6):481-7. doi: 10.1016/s0531-5565(82)80010-7.

Abstract

Histopathologic and autofluorescence investigations were carried out to study lipofuscin pigment accumulation in various age groups of human beings died in accidents (in 100 cases ranging from 1-70 years-of-age). Lipofuscin pigment granules were first observed to appear at 9 years of age. Qualitative studies revealed a progressive increase in the intracellular lipofuscin pigment accumulation with advancing age. These pigment granules were found to congregate in mass in nerve cells of old individuals. An increase in the lipofuscin pigment accumulation and decrease of Nissl substance was observed during aging. The percentage of pigmented nerve cells and the percentage of cytoplasmic area occupied by lipofuscin pigment granules increased significantly with the advancement of age.

摘要

进行了组织病理学和自体荧光研究，以研究死于事故的不同年龄组人类（100例，年龄范围为1至70岁）中脂褐素色素的积累情况。脂褐素色素颗粒首次在9岁时被观察到出现。定性研究表明，随着年龄的增长，细胞内脂褐素色素的积累逐渐增加。这些色素颗粒在老年人的神经细胞中大量聚集。在衰老过程中观察到脂褐素色素积累增加，尼氏体减少。随着年龄的增长，色素沉着神经细胞的百分比和脂褐素色素颗粒占据的细胞质面积百分比显著增加。