衰老过程中小鼠中枢神经系统中脂褐素色素的积累。
Lipofuscin pigment accumulation in the central nervous system of the mouse during aging.
作者信息
Goyal V K
出版信息
Exp Gerontol. 1982;17(2):89-94. doi: 10.1016/0531-5565(82)90041-9.
PMID:7106210
Abstract
Histopathological and autofluorescence investigations were carried out to study lipofuscin pigment accumulation in various age groups of mice. Qualitative studies revealed an increase of lipofuscin pigment accumulation in old animals. Quantitative studies showed a significant increase in the percentage of pigmented nerve cells and the percentage of cytoplasmic areas occupied by lipofuscin pigment granules with advancing age.
摘要
进行了组织病理学和自体荧光研究，以研究不同年龄组小鼠中脂褐素色素的积累情况。定性研究显示老年动物中脂褐素色素积累增加。定量研究表明，随着年龄的增长，色素沉着神经细胞的百分比以及脂褐素色素颗粒所占细胞质区域的百分比显著增加。
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